Originally developed by Upjohn Pharmacia and now manufactured by Pfizer Pharmaceuticals, Depo-Provera has been trusted worldwide for decades as a safe, reliable, and reversible contraceptive option. It also has additional clinical benefits in managing endometriosis and certain hormone-sensitive cancers.

At MedicarePharm, we offer authentic Pfizer Depo-Provera injections with discreet delivery and access to licensed medical support for women across the U.S., U.K., and Europe.

---

⚕️ Active Ingredient

Component	Strength	Function
Medroxyprogesterone Acetate (MPA)	150 mg/mL	A long-acting progestin that prevents ovulation and thickens cervical mucus to block sperm entry.

---

🩺 How Depo-Provera Works

Depo-Provera works by releasing a steady, low dose of Medroxyprogesterone, a synthetic form of the natural hormone progesterone. It prevents pregnancy through three mechanisms:

1️⃣ Stops ovulation — prevents the ovaries from releasing eggs.
2️⃣ Thickens cervical mucus — makes it difficult for sperm to reach the egg.
3️⃣ Thins the uterine lining — reduces the likelihood of implantation.

💡 With proper use, Depo-Provera is more than 99% effective, offering worry-free contraception for 12 weeks per injection.

---

💧 Dosage and Administration

Form: Sterile aqueous suspension in 1 mL vials (150 mg/mL).

Route: Deep intramuscular injection in the gluteal or deltoid muscle.

Schedule: Every 12–13 weeks (90 days).

🩸 First Injection:

Given within the first 5 days of menstruation for immediate protection.

If postpartum and not breastfeeding, injection can be given 5 days after delivery.

If breastfeeding exclusively, begin 6 weeks postpartum after ruling out pregnancy.

💉 Repeat Injections:

Administered every 90 days, ideally not delayed beyond 13 weeks to maintain full contraceptive protection.

⚠️ Shake the vial well before use to ensure even suspension. Must be injected intramuscularly — not subcutaneously.

---

🌼 Therapeutic Uses

Birth Control: Provides 3-month pregnancy protection per injection.

Endometriosis: Reduces pain and tissue growth through hormone suppression.

Hormone Therapy: Used as palliative treatment in breast, endometrial, and renal cancers that are hormone-sensitive.

Menstrual Disorders: Helps reduce excessive bleeding or painful periods (amenorrhea common after continued use).

---

🌟 Benefits of Depo-Provera

✔️ Highly effective — less than 1 pregnancy per 100 women per year.

✔️ Convenient — no daily pills or devices required.

✔️ Safe while breastfeeding — does not affect milk quantity or infant health.

✔️ Reduces risk of endometrial cancer for up to 8 years post-use.

✔️ Helps manage endometriosis and menstrual pain.

✔️ Ideal for women with sickle cell anemia due to reduced menstrual blood loss.

---

⚠️ Possible Side Effects

Common (mild and temporary):

Irregular or unpredictable bleeding (especially first months)

Headache, dizziness, or fatigue

Weight gain over time (average 2–6 kg within 1–4 years)

Mood changes or mild depression

Nausea, bloating, or abdominal discomfort

Breast tenderness or swelling

Less common:

Acne, hair loss, or excessive hair growth

Vaginal dryness or discharge

Joint or muscle pain

Serious (rare):
🚨 Bone mineral density loss (reversible upon discontinuation)
🚨 Blood clots, stroke, or hypertension
🚨 Jaundice or liver dysfunction
🚨 Allergic reaction or injection-site infection

💬 Note: Prolonged use (over 2 years) may increase risk of bone loss; calcium and vitamin D supplements are recommended.

---

⚕️ Contraindications

Do not use Depo-Provera if you:

Are pregnant or suspect pregnancy

Have unexplained vaginal bleeding

Have or had breast cancer or any hormone-sensitive tumor

Have blood clotting disorders, stroke, or severe hypertension

Suffer from active liver disease or abnormal liver function

Are allergic to Medroxyprogesterone or formulation ingredients

---

💬 Precautions

Use caution in patients with diabetes, osteoporosis, migraines, asthma, or heart/kidney disease.

Pap smear and blood pressure monitoring recommended before and during treatment.

Fluid retention may occur — especially in those prone to edema or heart conditions.

Pregnancy test required before initiation if menstrual irregularities occur.

---

🔬 Drug Interactions

Depo-Provera may alter laboratory test results, including:

Decreased plasma estrogen, progesterone, and cortisol levels

Altered glucose tolerance results

Changes in coagulation factor levels (II, VII, IX, X)

No major drug interactions reported with standard medications, but always inform your healthcare provider about ongoing treatments.

---

🩺 Clinical Considerations

🦴 Bone Health

Long-term use may lower estrogen levels and reduce bone mineral density (BMD). Women under 25 or with osteoporosis risk factors should limit use to 2 years, unless benefits outweigh risks.

👶 Return to Fertility

Fertility usually resumes within 11 months (range 9–12 months) after stopping Depo-Provera.

🤱 Breastfeeding

Safe for use during lactation — minimal transfer to breast milk with no reported adverse infant effects.

---

🌍 Why Choose Depo-Provera from MedicarePharm

💯 Original Pfizer-manufactured formulation

👩‍⚕️ Guidance from certified professionals

🔒 Secure packaging & discreet delivery

🚚 Fast global shipping (U.S., U.K., Europe)

💬 Comprehensive contraceptive counseling and aftercare

At MedicarePharm, we ensure trusted reproductive healthcare for women who seek safe, effective, and long-lasting contraception options — delivered privately and professionally.